ym 58483 Search Results


58483 4 methy 4 3 5 bis trifluoromethyl 1h pyrazol 1 yl 1 2 3 thiadiazole 5 carboxanilide  (Tocris)
94
Tocris 58483 4 methy 4 3 5 bis trifluoromethyl 1h pyrazol 1 yl 1 2 3 thiadiazole 5 carboxanilide
58483 4 Methy 4 3 5 Bis Trifluoromethyl 1h Pyrazol 1 Yl 1 2 3 Thiadiazole 5 Carboxanilide, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/58483 4 methy 4 3 5 bis trifluoromethyl 1h pyrazol 1 yl 1 2 3 thiadiazole 5 carboxanilide/product/Tocris
Average 94 stars, based on 1 article reviews
58483 4 methy 4 3 5 bis trifluoromethyl 1h pyrazol 1 yl 1 2 3 thiadiazole 5 carboxanilide - by Bioz Stars, 2026-03
94/100 stars
  Buy from Supplier
n 4  (MedChemExpress)
93
MedChemExpress n 4
N 4, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/n 4/product/MedChemExpress
Average 93 stars, based on 1 article reviews
n 4 - by Bioz Stars, 2026-03
93/100 stars
  Buy from Supplier
btp2  (Selleck Chemicals)
91
Selleck Chemicals btp2
MBL inhibited EMT phenotype through limited SOCE calcium signaling. a–f HBE cells were stimulated with 10-ng/mL TGF-β in the presence or absence of 10-μg/mL MBL for 24 h. In some case, cells were also treated with 3-μM <t>BTP2.</t> a FCM analysis was performed to detect cellular calcium. b SOCE calcium signaling was assessed by a confocal laser scanning microscope. c Cellular calcium was determined by FCM assay. d A wound healing assay was used to evaluate cell migration. e Quantitative RT-PCR analysis was performed to assay E-cadherin, N-cadherin, α-SMA, and vimentin mRNA expression. f E-cadherin, N-cadherin, α-SMA, and vimentin levels were tested by Western blot analysis. g–i WT and MBL −/− mice ( n = 5) were intratracheally injected with 5-mg/kg BLM combined with 10-mg/kg BTP2 for 21 days. g Histological analysis of mouse lungs was determined by H&E staining. Scale bar, 100 μm. h mRNA levels of E-cadherin, N-cadherin, α-SMA, and vimentin were evaluated by quantitative RT-PCR. i E-cadherin, N-cadherin, α-SMA, and vimentin expression were assessed by western blot analysis. ns, not significant, * p < 0.05, ** p < 0.01. The data represent three independent experiments with similar results. Unpaired Student's t test was used in a–d and h . e One-way ANOVA, followed by Dunnett's post hoc test was used in e .
Btp2, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/btp2/product/Selleck Chemicals
Average 91 stars, based on 1 article reviews
btp2 - by Bioz Stars, 2026-03
91/100 stars
  Buy from Supplier
ym 58483  (Tocris)
93
Tocris ym 58483
MBL inhibited EMT phenotype through limited SOCE calcium signaling. a–f HBE cells were stimulated with 10-ng/mL TGF-β in the presence or absence of 10-μg/mL MBL for 24 h. In some case, cells were also treated with 3-μM <t>BTP2.</t> a FCM analysis was performed to detect cellular calcium. b SOCE calcium signaling was assessed by a confocal laser scanning microscope. c Cellular calcium was determined by FCM assay. d A wound healing assay was used to evaluate cell migration. e Quantitative RT-PCR analysis was performed to assay E-cadherin, N-cadherin, α-SMA, and vimentin mRNA expression. f E-cadherin, N-cadherin, α-SMA, and vimentin levels were tested by Western blot analysis. g–i WT and MBL −/− mice ( n = 5) were intratracheally injected with 5-mg/kg BLM combined with 10-mg/kg BTP2 for 21 days. g Histological analysis of mouse lungs was determined by H&E staining. Scale bar, 100 μm. h mRNA levels of E-cadherin, N-cadherin, α-SMA, and vimentin were evaluated by quantitative RT-PCR. i E-cadherin, N-cadherin, α-SMA, and vimentin expression were assessed by western blot analysis. ns, not significant, * p < 0.05, ** p < 0.01. The data represent three independent experiments with similar results. Unpaired Student's t test was used in a–d and h . e One-way ANOVA, followed by Dunnett's post hoc test was used in e .
Ym 58483, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ym 58483/product/Tocris
Average 93 stars, based on 1 article reviews
ym 58483 - by Bioz Stars, 2026-03
93/100 stars
  Buy from Supplier
btp2 (ym- 58483)  (Cambridge Bioscience)
90
Cambridge Bioscience btp2 (ym- 58483)
MBL inhibited EMT phenotype through limited SOCE calcium signaling. a–f HBE cells were stimulated with 10-ng/mL TGF-β in the presence or absence of 10-μg/mL MBL for 24 h. In some case, cells were also treated with 3-μM <t>BTP2.</t> a FCM analysis was performed to detect cellular calcium. b SOCE calcium signaling was assessed by a confocal laser scanning microscope. c Cellular calcium was determined by FCM assay. d A wound healing assay was used to evaluate cell migration. e Quantitative RT-PCR analysis was performed to assay E-cadherin, N-cadherin, α-SMA, and vimentin mRNA expression. f E-cadherin, N-cadherin, α-SMA, and vimentin levels were tested by Western blot analysis. g–i WT and MBL −/− mice ( n = 5) were intratracheally injected with 5-mg/kg BLM combined with 10-mg/kg BTP2 for 21 days. g Histological analysis of mouse lungs was determined by H&E staining. Scale bar, 100 μm. h mRNA levels of E-cadherin, N-cadherin, α-SMA, and vimentin were evaluated by quantitative RT-PCR. i E-cadherin, N-cadherin, α-SMA, and vimentin expression were assessed by western blot analysis. ns, not significant, * p < 0.05, ** p < 0.01. The data represent three independent experiments with similar results. Unpaired Student's t test was used in a–d and h . e One-way ANOVA, followed by Dunnett's post hoc test was used in e .
Btp2 (Ym 58483), supplied by Cambridge Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/btp2 (ym- 58483)/product/Cambridge Bioscience
Average 90 stars, based on 1 article reviews
btp2 (ym- 58483) - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
pyrazole derivative ym-58483 (btp2)  (Astellas)
90
Astellas pyrazole derivative ym-58483 (btp2)
MBL inhibited EMT phenotype through limited SOCE calcium signaling. a–f HBE cells were stimulated with 10-ng/mL TGF-β in the presence or absence of 10-μg/mL MBL for 24 h. In some case, cells were also treated with 3-μM <t>BTP2.</t> a FCM analysis was performed to detect cellular calcium. b SOCE calcium signaling was assessed by a confocal laser scanning microscope. c Cellular calcium was determined by FCM assay. d A wound healing assay was used to evaluate cell migration. e Quantitative RT-PCR analysis was performed to assay E-cadherin, N-cadherin, α-SMA, and vimentin mRNA expression. f E-cadherin, N-cadherin, α-SMA, and vimentin levels were tested by Western blot analysis. g–i WT and MBL −/− mice ( n = 5) were intratracheally injected with 5-mg/kg BLM combined with 10-mg/kg BTP2 for 21 days. g Histological analysis of mouse lungs was determined by H&E staining. Scale bar, 100 μm. h mRNA levels of E-cadherin, N-cadherin, α-SMA, and vimentin were evaluated by quantitative RT-PCR. i E-cadherin, N-cadherin, α-SMA, and vimentin expression were assessed by western blot analysis. ns, not significant, * p < 0.05, ** p < 0.01. The data represent three independent experiments with similar results. Unpaired Student's t test was used in a–d and h . e One-way ANOVA, followed by Dunnett's post hoc test was used in e .
Pyrazole Derivative Ym 58483 (Btp2), supplied by Astellas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pyrazole derivative ym-58483 (btp2)/product/Astellas
Average 90 stars, based on 1 article reviews
pyrazole derivative ym-58483 (btp2) - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
ym-58483  (Yamanouchi Pharmaceutical Co)
90
Yamanouchi Pharmaceutical Co ym-58483
MBL inhibited EMT phenotype through limited SOCE calcium signaling. a–f HBE cells were stimulated with 10-ng/mL TGF-β in the presence or absence of 10-μg/mL MBL for 24 h. In some case, cells were also treated with 3-μM <t>BTP2.</t> a FCM analysis was performed to detect cellular calcium. b SOCE calcium signaling was assessed by a confocal laser scanning microscope. c Cellular calcium was determined by FCM assay. d A wound healing assay was used to evaluate cell migration. e Quantitative RT-PCR analysis was performed to assay E-cadherin, N-cadherin, α-SMA, and vimentin mRNA expression. f E-cadherin, N-cadherin, α-SMA, and vimentin levels were tested by Western blot analysis. g–i WT and MBL −/− mice ( n = 5) were intratracheally injected with 5-mg/kg BLM combined with 10-mg/kg BTP2 for 21 days. g Histological analysis of mouse lungs was determined by H&E staining. Scale bar, 100 μm. h mRNA levels of E-cadherin, N-cadherin, α-SMA, and vimentin were evaluated by quantitative RT-PCR. i E-cadherin, N-cadherin, α-SMA, and vimentin expression were assessed by western blot analysis. ns, not significant, * p < 0.05, ** p < 0.01. The data represent three independent experiments with similar results. Unpaired Student's t test was used in a–d and h . e One-way ANOVA, followed by Dunnett's post hoc test was used in e .
Ym 58483, supplied by Yamanouchi Pharmaceutical Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ym-58483/product/Yamanouchi Pharmaceutical Co
Average 90 stars, based on 1 article reviews
ym-58483 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
ym-58483  (Putney Inc)
90
Putney Inc ym-58483
MBL inhibited EMT phenotype through limited SOCE calcium signaling. a–f HBE cells were stimulated with 10-ng/mL TGF-β in the presence or absence of 10-μg/mL MBL for 24 h. In some case, cells were also treated with 3-μM <t>BTP2.</t> a FCM analysis was performed to detect cellular calcium. b SOCE calcium signaling was assessed by a confocal laser scanning microscope. c Cellular calcium was determined by FCM assay. d A wound healing assay was used to evaluate cell migration. e Quantitative RT-PCR analysis was performed to assay E-cadherin, N-cadherin, α-SMA, and vimentin mRNA expression. f E-cadherin, N-cadherin, α-SMA, and vimentin levels were tested by Western blot analysis. g–i WT and MBL −/− mice ( n = 5) were intratracheally injected with 5-mg/kg BLM combined with 10-mg/kg BTP2 for 21 days. g Histological analysis of mouse lungs was determined by H&E staining. Scale bar, 100 μm. h mRNA levels of E-cadherin, N-cadherin, α-SMA, and vimentin were evaluated by quantitative RT-PCR. i E-cadherin, N-cadherin, α-SMA, and vimentin expression were assessed by western blot analysis. ns, not significant, * p < 0.05, ** p < 0.01. The data represent three independent experiments with similar results. Unpaired Student's t test was used in a–d and h . e One-way ANOVA, followed by Dunnett's post hoc test was used in e .
Ym 58483, supplied by Putney Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ym-58483/product/Putney Inc
Average 90 stars, based on 1 article reviews
ym-58483 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
ym-58483  (Synta Inc)
90
Synta Inc ym-58483
MBL inhibited EMT phenotype through limited SOCE calcium signaling. a–f HBE cells were stimulated with 10-ng/mL TGF-β in the presence or absence of 10-μg/mL MBL for 24 h. In some case, cells were also treated with 3-μM <t>BTP2.</t> a FCM analysis was performed to detect cellular calcium. b SOCE calcium signaling was assessed by a confocal laser scanning microscope. c Cellular calcium was determined by FCM assay. d A wound healing assay was used to evaluate cell migration. e Quantitative RT-PCR analysis was performed to assay E-cadherin, N-cadherin, α-SMA, and vimentin mRNA expression. f E-cadherin, N-cadherin, α-SMA, and vimentin levels were tested by Western blot analysis. g–i WT and MBL −/− mice ( n = 5) were intratracheally injected with 5-mg/kg BLM combined with 10-mg/kg BTP2 for 21 days. g Histological analysis of mouse lungs was determined by H&E staining. Scale bar, 100 μm. h mRNA levels of E-cadherin, N-cadherin, α-SMA, and vimentin were evaluated by quantitative RT-PCR. i E-cadherin, N-cadherin, α-SMA, and vimentin expression were assessed by western blot analysis. ns, not significant, * p < 0.05, ** p < 0.01. The data represent three independent experiments with similar results. Unpaired Student's t test was used in a–d and h . e One-way ANOVA, followed by Dunnett's post hoc test was used in e .
Ym 58483, supplied by Synta Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ym-58483/product/Synta Inc
Average 90 stars, based on 1 article reviews
ym-58483 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

Image Search Results


MBL inhibited EMT phenotype through limited SOCE calcium signaling. a–f HBE cells were stimulated with 10-ng/mL TGF-β in the presence or absence of 10-μg/mL MBL for 24 h. In some case, cells were also treated with 3-μM BTP2. a FCM analysis was performed to detect cellular calcium. b SOCE calcium signaling was assessed by a confocal laser scanning microscope. c Cellular calcium was determined by FCM assay. d A wound healing assay was used to evaluate cell migration. e Quantitative RT-PCR analysis was performed to assay E-cadherin, N-cadherin, α-SMA, and vimentin mRNA expression. f E-cadherin, N-cadherin, α-SMA, and vimentin levels were tested by Western blot analysis. g–i WT and MBL −/− mice ( n = 5) were intratracheally injected with 5-mg/kg BLM combined with 10-mg/kg BTP2 for 21 days. g Histological analysis of mouse lungs was determined by H&E staining. Scale bar, 100 μm. h mRNA levels of E-cadherin, N-cadherin, α-SMA, and vimentin were evaluated by quantitative RT-PCR. i E-cadherin, N-cadherin, α-SMA, and vimentin expression were assessed by western blot analysis. ns, not significant, * p < 0.05, ** p < 0.01. The data represent three independent experiments with similar results. Unpaired Student's t test was used in a–d and h . e One-way ANOVA, followed by Dunnett's post hoc test was used in e .

Journal: Journal of Innate Immunity

Article Title: Mannan-Binding Lectin Reduces Epithelial-Mesenchymal Transition in Pulmonary Fibrosis via Inactivating the Store-Operated Calcium Entry Machinery

doi: 10.1159/000524693

Figure Lengend Snippet: MBL inhibited EMT phenotype through limited SOCE calcium signaling. a–f HBE cells were stimulated with 10-ng/mL TGF-β in the presence or absence of 10-μg/mL MBL for 24 h. In some case, cells were also treated with 3-μM BTP2. a FCM analysis was performed to detect cellular calcium. b SOCE calcium signaling was assessed by a confocal laser scanning microscope. c Cellular calcium was determined by FCM assay. d A wound healing assay was used to evaluate cell migration. e Quantitative RT-PCR analysis was performed to assay E-cadherin, N-cadherin, α-SMA, and vimentin mRNA expression. f E-cadherin, N-cadherin, α-SMA, and vimentin levels were tested by Western blot analysis. g–i WT and MBL −/− mice ( n = 5) were intratracheally injected with 5-mg/kg BLM combined with 10-mg/kg BTP2 for 21 days. g Histological analysis of mouse lungs was determined by H&E staining. Scale bar, 100 μm. h mRNA levels of E-cadherin, N-cadherin, α-SMA, and vimentin were evaluated by quantitative RT-PCR. i E-cadherin, N-cadherin, α-SMA, and vimentin expression were assessed by western blot analysis. ns, not significant, * p < 0.05, ** p < 0.01. The data represent three independent experiments with similar results. Unpaired Student's t test was used in a–d and h . e One-way ANOVA, followed by Dunnett's post hoc test was used in e .

Article Snippet: In some cases, mice were injected combined with 10-mg/kg BTP2 (S8380; Selleck).

Techniques: Laser-Scanning Microscopy, Wound Healing Assay, Migration, Quantitative RT-PCR, Expressing, Western Blot, Injection, Staining